Make the meatloaf mixture. In a large bowl, add the meatloaf ingredients: 2 pounds ground beef, 1 cup of plain breadcrumbs, 2 large, room temp and beaten eggs, ¼ cup diced red bell pepper, ¼ cup diced green bell pepper, ¼ cup ketchup. Then, add the seasoning: ¼ teaspoon each of salt, ground black pepper, garlic powder, and onion powder.